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GlaxoSmithKline Plc is a healthcare company which engages in the research, development and manufacture of pharmaceutical medicines, vaccines and consumer healthcare products. It operates through the following segments: Pharmaceuticals, Vaccines, Consumer Healthcare and Corporate Executive Team (CET). The Pharmaceuticals segment focuses on developing medicines in respiratory and infectious diseases, oncology and immuno-inflammation. The Vaccines segment produces pediatric and adult vaccines to prevent a range of infectious diseases including hepatitis A and B, diphtheria, tetanus and whooping cough, measles, mumps and rubella, polio, typhoid, influenza and bacterial meningitis. The Consumer Healthcare segment develops and markets brands in the oral health, pain relief, respiratory, nutrition & gastro intestinal and skin health categories. The CET segment refers to the management of business activities. The company began in 1715 and is headquartered in Middlesex, the United Kingdom.